Dear, Hou-Ying Yau. The so-called virtual particles can not be observed, since, otherwise, would be "real"
But these virtual particles, not observable, are the foundation of ad-hoc method of renormalization, which leads to the unwanted infinities. It contradicts the Copenhagen interpretation, since no observable particles, not real, according to this interpretation, are what determine all calculations, and therefore are real deterministically. Excellent, your point of view. One of the keys, I agree: the loss of information of a system that deep down, most likely, is not as indeterministic as presented now by the quantum theory.
It is possible that the interference of measurement or observation, with a local system disturbs a unitary space-time-energy, non-local, because in reality the space-time-energy would be a continuous quantized, not separable.
The information he lost to the observer causes. This appears to the observer probabilistic knowledge, but this does not mean that there is no underlying reality independent of the observer, as evidenced by the existence of unobservable particles, but that influence the so-called "real" world. For example, the effect Cassimir, measured experimentally