Hello Giovanni,
I found your essay one of the best I've read, and you argue very well for weaknesses in the spacetime interpretation at a small scale in some areas. But you talk as if all is well with spacetime elsewhere and generally, as intuition says it should be. Of course SR is right, but a close look and you'll see that all is not well generally with the spacetime interpretation. You say:
"The redundant abstraction of a macroscopic spacetime organizing all our particle detections is unproblematic and extremely useful in the classical-mechanics regime."
In fact it is not 'unproblematic', as spacetime leads unavoidably via a rigourous proof to block time, which requires motion through time not to exist, which in turn removes cause and effect. This loss of cause and effect is somewhat problematic in the classical mechanics regime.
You also say:
"Of course, the spacetime abstraction is unrenounceably convenient for organizing and streamlining our description of observations done in the classical-mechanics regime."
That is all true, except for the word 'unrenounceably'. It is convenient, and it seems harmless. But we don't understand time, and Minkowski spacetime contains a set of assumptions about time. Because we don't understand time, we have to look at the clues about time, as I've argued in my essay. If we don't look at the clues in front of us, however unexpected, I'm not sure how we're going to reach a point where we understand time. There are also missing pieces of the puzzle, and we need to allow for their existence.
Because it leads to block time, spacetime is in contradiction with the standard view of quantum theory about whether the future currently exists. That is a deep contradiction. And there are some places where the implications of spacetime jar with our picture that deeply, and conflict directly with what we observe. So although it is convenient to use, it looks like it might be flawed.
This means it is not like your analogy with the aether, which was portrayed in your quote as a useful concept, whether or not it actually exists. You sound almost like it makes little difference whether spacetime exists - and yet if it does exist, motion through time doesn't, and if it doesn't, motion through time can. That's a big difference.
So to me, you've not gone far enough in criticising spacetime, and could have strengthened your argument by pointing out other weaknesses. Of course SR is right, that has been extremely well confirmed by experiment. But the spacetime interpretation has not been confirmed, and if one gets conceptual problems with an interpretation, then one probably needs a new interpretation.
I'd appreciate any thoughts you might have on my essay. Yours and mine together show the problems with spacetime very well, though they deal with different areas.
Good luck. Best wishes,
Jonathan