Philip
Leaving aside the specific context, the general point being made here is not philosophy, but a fact. There is no way that any form of sensing can be so refined that it is capable of differentiating one physically existent state from another. The degree of alteration is too small, we are reliant on the caability of light (in sight) to discern it and convey it, sensory systems and technology is inadequate. Put another way, there is a simple IKEA wastebasket to my left. With the most advanced technology available and a million years to analyse the results, I bet a singular physically existent state of that entity would still not be defined accurately and comprehensively.
We are kidding ourselves. But, obviously, so long as we do understand the limitations, and deploy proper hypothess, then progress can be made. But as always, it makes sense to understand the true nature of what is being considered first. That is, do not turn up to woodworking classes with a toothpick and a lawnmower, as these may be tools, but in the context of the nature of wood, they are useless.
Paul