Dear Charles,
I am impressed by the breadth of the historical context that you laid out surrounding the contest theme. Several others had mentioned and compared von Weizsaecker's contributions to the debate, but yours is the most extensive I have read. Given that evidently many different physicists worked on it and its development spanned several decades, I wonder why it was never developed beyond essentially being the blueprint for a theory. There may be lessons for us to draw from knowing the reasons.
I also found the comparison of the missing 'additional ingredient' in Spekkens' toy theory with quinian bootstrap surprising, though I must admit that I am skeptical that they are the same. The former seems like a leap in a territory that is much more abstract than that which characterizes the context of the leap in the latter.
I was originally attracted to reading your essay because the title sounded to like a contradition, and I wanted to find out how you would "pull off" considering information as a substance. Your pointing out the most basic etymological meaning of substance, however, has clarified things for me.
My own view is that a fundamental message of the Born rule is that our current concept of "substance" (in the usual sense) is not sufficiently differentiated and if we could realize this, we would come to regard it vs. bit a false dichotomy.
In any event, I found your essay and its elucidation of the historical context of this debate very interesting.
All the best,
Armin