Dear Guido,
You proposal of addressing the question of the emergence of science is quite to the point for this contest. You are showing an important direction.
Your citation of Einstein is interesting, pertinent, and new to me.
Most of the ideas you state are sound, and you could have probably avoided a too detailed exposition of your elaborated and complex model of autonomous agents and embodied cognitive science, neural networks and the like, which eventually add little to the strength of your ideas. You would have saved more room to develop the consequences of your considerations, and I would have enjoyed reading more.
I completely agree with your early point: ``it is hard to find a reasonable degree of abstraction for starting a program like "deriving science from observer properties".''
When then you conclude that ``we should not model observers mathematically as part of theories of physics/science since we neglect in this way many relevant observer-model properties'', however, I entirely agree when I place myself in the frame of your essay, but neglecting aspects of what we perceive to extract patterns is the core of processes of perception, and as a consequence of science. Thus any possibility of a new and fruitful viewpoint on building science in the frame of observers will proceed in this way --but I completely agree that all the challenge is to retain relevant properties, and to find the right level of abstraction.
Incidentally, this is exactly my essay's attempt.
Regards,