I think Bousso's approach is very interesting. We do need to get to the bottom of physics and must be possible to find it when we get rid of those pesky infinities. I think even one should go one step further and make the physics version of the Hilbert program - a search for the really fundamental building material of the universe. Maybe the Bousso program?
My - not entirely scientific - view, is that there are three necessary components; causality, entanglement, and chance (randomness), that compose the basis for time, energy, matter and all the wonderful higher-level phenomenon we perceive. Causality is necessary for a non-static solution and leads to what we think of as time. Entanglement is necessary for building structures. Chance is necessary together with causality and entanglement to let structures evolve.
The goal must be to find the simplest possible way to describe this. I think f.ex that it is not very productive to focus on something like quantum bits - it is the relation that makes up a structure.
This is however only possible if the universe is finite. If the definition - "A universe is a collection with information that has a non-zero chance of interacting." - holds, the universe must be finite. (I really hope some other than me will prove it or prove it false and maybe it is enough with a variant of the associative law)
Anyway - no matter how this is solved, it should be valuable to combat all the "mysticism" that sneaks in when there a concept we humans don't understand.