Dear Brian,
Many thanks for your thought-provoking essay and my introduction to biosemiotics.* In return, there follows one of the just-mentioned thoughts: offered at the risk of my being scheduled as biosemiidiotic (if not wholly so).
Seeking to understand (and give meaning to) your symbols, it seemed that you were in fact talking (somewhat in code) about me [well, certainly about some of my friends; but they can speak for themselves]. For, like them, I believe myself to be an element of the set X = {biological | spacetime}: renown for my agency, as in my doings, performances, actions; AKA getting things done.
Further, in accord with your thesis, I like to think that I do now take (from p.1) "proper account of the phenomenon of meaning." For example: Having learnt to read at early age, I could give meaning to the symbols at the local bus-stop. It read: "BUS STOP. SIGNAL DRIVER." And though I only ever saw one driver per bus, yet I knew it was not a typo. For I also knew that "signal" had two meanings: and it could not be the common one, for it already said bus STOP. Thus did I see that they were reassuringly advertising the outstanding safety of each driver. [Only later did I learn, standing there, that the driver did not stop unless you waved (action); accompanied by great future insecurity (he might miss your action): whereas the one consistent message -- to my small mind -- lead to inaction by me, certain stopping by the bus, and an assured long-term security.]
All of which brings me to this next (p.1): "Meaning fails to show up in the world of physics simply because the kind of situations that physicists prefer to investigate are ones where meaning has no significant influence on the outcome." Yes, indeed! Consider the famous case of Bell's theorem: the meaning one attaches to REALISM significantly influences ones' understanding of REALITY. For me, "true realism" proves to be consistent with locality; for others, "naive realism" leads to dilemmas about AAD and nonlocality.
I could go on about theorising and scaffolding; to the edge of chaos; confusing readers; your [BJ] personal benefits (p.5). But I want to focus on this: "Historians will marvel at the way insistence by the mainstream that at a fundamental level particles are the only things that matter, banishing to the fringe those scientists who think otherwise, will be seen to have drastically interfered with the progress of science" (p.6).
I AGREE: For while I take "existence" to be fundamental, it is "interference; AKA interaction" that provides the doings, performances, actions of our dynamic universe: and particles. Thus do I believe that introductions to biosemiotics should focus on personal/human analogies from set X re scaffolding to the edge of chaos; etc.
* My only acquaintance with C. S. Peirce is that I called upon him to prove a point re the last word in my title: More realistic fundamentals: quantum theory from one premiss.
PS: Brian, to help promote your lovely essay, I'll put the above on my essay-site. Thus -- if/when you respond -- please post a note there so that I'm alerted.
With my thanks again, and with my best regards; Gordon