I've been fascinated since the 1996 "Towards a Science of Consciousness", finding out that Brian branched out to explore the more personal. meaningful, interpretive aspects of sentient experience. And have been grateful for the few minutes of conversation at various conferences - such as in Holland with the topic of Emergence.
I wholehearted agree that conventional science modeling is insufficient, and likely has some deficiencies in it for it to grasp, let alone express and discuss, the grandeur of our universe .. which by default has to include .. 'fundamentals'.
I am curious Brian, why you didn't reference/mention cybernetics? "Meaning" is a very valuable qualia to include in any TOE. And I think, as many do, that a physics-based criteria for a TOE is to not only exclude the associated relevance of all the vaster complexities and tiers of organizations, but, to mentally dismiss all of that with the wave of a verbal hand,"Those are -just- emergent properties, secondary and 'less' in value or importance in some sense, to the primal constructs of existence."
Not so, not so at all. Because we would otherwise have to posit that emergence produces novel 'fundamentals' or entity/relations that have no relevance or precursive presence in the preceding tiers and events and processes.
Your stressing the word "meaning", is something that Wiener and cybernetics identified as -very- relevant. In fact, I would suggest "meaning" is a word that conveys that association relationship as a synonym .. "relevance". Even if experienced in other frames of reference ... colors versus wave lengths ; language~music versus 'vibrations'. Because each tier of organization has its own sensing~engaging apparatus .. organelles, as it were.
Your designation of Josephson Junction (JJ) ... is a quantum states mechanism of data transference .. meaningfully retained data sets .. from transmitter to receiver.
And so I enjoy your efforts to awaken thinkers to that truth. Behaviors and actions in one tier of existence has interpretive coherent cybernetic -relevance- in other tiers of complex structures .. and should be naturally appreciated as shared interrelated .. associated .. qualia~phenomena~data.
A physics only 'TOE" is, as another friend of mine describes .. really a narrow blindered .. theory of SOMEthings. Even if everything is constructed of those minimalist particles ~waves. And Artificial Intelligence (AI) should more properly be called SI .. SIMULATED intelligence. Especially since life sentience is structured as 'hardware is software', versus hardware carrying software. JJ's are a seminal example. Sender~receiver states change across a separation. They physically fundamentally "re-form" .. and the information moves along -as- the new quantum states or metabolic structures changes.
So somewhere, somehow, deep inside the physics events, are unconsidered 'relevances' .. natural meanings that the particles and waves have with each other. Which are the "primitives" .. which have the capacity to cybernetically contribute to next tiers of organization, as they interact into higher complications .. of added relevance.
James Rose
(*apologies for any typos :-) )