This essay argues that physiology requires quantum mechanics, synthesizes evidence across catalysis, metabolism, homeostasis, and cell signaling, and proposes an intracellular Quantum Biology Device (QBD) for direct in vivo tests. It also outlines the design of the QBD, describes representative experiments, and discusses potential translational consequences. Skeptical counterarguments are raised and rebutted. Confronting life’s quantum foundations shows that physiology cannot be fully understood without quantum mechanics, and building tools such as the QBD will both resolve fundamental scientific debates and unlock transformative advances in biology and medicine.
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