John,
You have raised some interesting points. Rather than comment directly on them myself I'd prefer to get George's own views; he clearly has given this topic far more thought than I have, and probably far more than both of us combined.
It certainly is a fascinating topic. David Deutsch has offered what strikes me as a classic comment on the topic in his book 'The Fabric of Reality' as follows (apologies for the odd spacing; I know not how to fix it):
"For example, consider
one particular copper atom at the tip of the nose of the statue
of Sir Winston Churchill that stands in Parliament Square in
London. Let me try to explain why that copper atom is there. It
is because Churchill served as prime minister in the House of
Commons nearby; and because his ideas and leadership contributed
to the Allied victory in the Second World War; and because it is
customary to honor such people by putting up statues of them;
and because bronze, a traditional material for such statues,
contains copper, an so on. Thus we explain a low-level physical
observation-- the presence of a copper atom at a particular
location-- through extremely high-level theories about emergent
phenomena such as ideas, leadership, war and tradition.
There is no reason why there should exist, even in
principle, any lower-level explanation of the presence of
that copper atom than the one I have just given."
jcns