Manuel
"There is indeed an answer to ALL of this and yes it does transcend our existence. This 'knowledge' of existence is not the starting point"
I am surprised by this response, because I thought that was the simple bit. There is existence of some form or other. We are enabled to be aware of it through a physical process (forget how proficient we are at identifying all there is to be aware of, and the accuracy with which we do so). This means that what we can know has to be regarded as possibly only one form of existence. However that is irrelevant in so far as it is all we can potentially know, ie we must just accept that there may be an alternative. The important point is that we can only know, and we can only know what is potentially knowable. This is the existentially closed system within which we are trapped. We can of course invoke any belief (ie knowledge without any experienceable-direct or hypothetical-substantiation), but that is not science.
In simple terms, we could, though it is very unlikely in many areas, eventually know all there is that is knowable. We will become aware of this by default, because we can only know from within the closed system, ie after sufficient time and continued investigation, no new knowledge arises. Now, this is not the same as knowing everything/what is ultimately happening/or any other such phrase. Because there is always the possibility of an alternative, and we cannot transcend our own existence. Neither is this the same as hypothesis, proper hypothesis being in effect virtual sensing. That is, it follows the rules of sensing and overrides certain identifiable issues in order to establish what could have been sensed had we been able to do so.
This seems to be a key statement: "If we are to uncover the fundamental interaction
of our physical universe then we need to establish what is causal and what is not. Here we find Wheeler's 'it from bit' doctrine of how physical laws are cast as states of information to be insufficient by not stating how those states of 'bit' came to exist in the first place". This is not true. We cannot know how or why whatever comprises our existence occurred. We can only arrive back at a logical start point based on an understanding of what has subsequently occurred. Neither does this assist in identifying the fundamental interaction(s). Something, or a range of such, is causing alteration in whatever comprises existence (which may also be a range of types). Indeed, these two may be different aspects of the same thing (or things) but that is detail(!). The important point is that something is 'going on', and we need to find out what that is. But what is 'gong on' is only manifest to us in what might be a particular form, ie we can only know what is 'going on' as it is potentially knowable to us. And that is difficult enough, and in many case unachievable, but the potential is there. We then just have to accept we can know no more.
Reality is not pre-determined. It appears to be so because it is functioning to certain rules. Another way of expressing this is to identify what, in generic terms, a reality is. And that is a discrete, definitive, physically existent state of whatever comprises it at that time. Existence necessitates discrete/definitive, which is where relativity/QM has gone wrong, because they, effectively, assert some form of indefiniteness in reality. They did not mean to, which goes back to my first post. I am not sure that anybody is consciously stating anything other than cause trumps effect ( to use your phrase). The differential is between what was said and, given a proper understanding of reality, what that can actually mean. [Incidentally what we do and think is irrelevant to the physical circumstance, because it has already occurred. Or in the case of the 'future', it has not occurred, ie something then occurs which is different to what would have otherwise have done so. But that is just a definition of cause/effect, so is meaningless. The future is not pre-existent. But I do not think you are saying any of this].
Paul