Dear Laurence,
As I see it, the situation is this. There are three possible positions on the direction of time: 1) there is no directionality to time at all--the direction from this event to the past is physically just like the direction from this event to the future--; 2) there is a directionality, but it is not fundamental but rather should be analyzed in terms of something else (e.g. an entropy gradient). Note that on a view like this, using the entropy gradient to define the direction it comes out analytic that entropy never decreases, since the direction to higher entropy is the forward direction. The "direction of time" can flip around on this view if entropy behaves the right way. This is not what we normally say: we say that the entropy of (say) a gas in a box can go down, and even does go slightly done, even if on average it goes up. 3) The direction of time is a real, physical difference between the time directions, and does not get reduced to or analyzed in terms of anything else. Huw holds 1), I hold 3), and lots of people hold 2) offering different sorts of analyses.
If you hold 3), then the best one can ask for from mathematical physics is a clear mathematical representation of this directionality. Since we are talking about an intrinsic directionality in space-time geometry, one would need a geometrical language in which directionality can be naturally represented. In standard topology, this is not true. If I ask you to "put a direction" on an open set of points, it is not at all clear what I am asking you to do. But lines, in contrast, are exactly characterized by having only two directions on them. Indicating that these directions are physically different is just a matter of associating one of the two possible directions with the line. This is what can be done using Directed Linear Structures: if the lines have directions, the geometry becomes intrinsically directional. There is no standard topology analog for this at all.
Now we push further: if space-time has an intrinsically directed geometry, what is the source of the directionality, the directional asymmetry? In Relativity, there is a very natural answer: the directionality is produced by the asymmetric nature of time. Some pairs of events (but not all) can be characterized by an asymmetric temporal earlier/later distinction. And in Relativity (but not classical space-time) that distinction alone is enough to recover almost all of the space-time geometry: everything up to the conformal structure. The whole light-cone structure gets built in, and indeed a complete Directed Linear Structure can be defined. So the picture is that the fundamental asymmetry of time creates a fundamentally directed space-time geometry. And this can be done for both continuous and discrete structures.
In sum, if you think time is intrinsically asymmetric (unlike Price), standard topology provides no way to easily represent that feature of the geometry and the Theory of Linear Structures does. That is not itself an argument for the directionality. But it is a response to someone who says: "I don't see any time asymmetry in the math!". That, of course, depends on what mathematical language you are using to represent the physical situation. Maybe it is hard to see the directionality in the math because you are using math that does not have a simple way to represent directionality.
I hope this is some help,
Cheers,
Tim