Matthew Leifer I'm not entirely sure that the difference between the 5-sigma standard of discovery in particle physics and the 1- or 2-sigma standard of discovery in, say, biology is really an example of what Kuhn had in mind. My understanding of Kuhn was that the very methodology of science was subjective. A difference in accuracy standards isn't really a difference in methodology.
Having said that, I am no fan of Kuhn and I think that denying some kind of universal objective "truth" is a dangerous thing. While there are numerous philosophical examples one could give, the practical example I am particularly fond of using is the following. I teach a course on climate change that is open to scientists and non-scientists alike. I often get (in fact I deliberately target) students who don't believe it's real or, if it is, that's it's not a man-made problem. The entire point of the class is to convince them otherwise by working through the science. If Kuhn is right then science is nothing more than another form of propaganda and its entire edifice (not to mention all that accompanies it -- vaccines, technology, etc.) falls apart.